A Pulsed DC Electric Field Affects P2-Purinergic Receptor Functions by Altering the ATP Levels in Vitro and in Vivo Systems

Recently it was shown that extracellular ATP, acting through purinergic receptors, has many physiological functions, including opening of Ca2+ -ion channels, activation and mediation of signal transduction mechanisms as well as activation of the pain sensation. Since electrical stimulation is also known to affect many signal transduction processes, this study explores the relationship between electric fields and ATP levels.