Activation of Signal-Transduction Mechanisms May Underlie the Therapeutic Effects of an Applied Electric Field

There are numerous reports of positive clinical effects after exposure to applied electric fields of relatively small strength (in the 103 to 104 V m–1 range) which are variable with low to medium frequency (below 150 Hz). Effects reported include the alleviation of pain, decreased inflammation, wound and bone fracture healing, and enhanced tissue regeneration.